NUCLEAR AND CELL MORPHOMETRY OF ENDOMETRIOID OVARIAN CANCER IN ASSESSMENT OF TUMOR METASTASIS
E.V. Novichkov, O.V. Vorobieva, O.N. Novichkova
The aim of our study was to study the morphological features of tumor parenchyma taking into account the patterns of progression of endometrioid ovarian cancer. Morphometric signs of the high risk for metastasis of endometrioid ovarian cancer are the increased area of tumor cells (p=0,36) and nuclei (p=0,38) with the simultaneous increase in nuclear/cell ratio (p=0,049). Metastatic endometrioid tumors of the female gonads are featured by cube-shaped cells, which number in the field of view exceeded 28,3±2,46, p=0.043. The larger size of the cancer cells (p=0,012) associated with high cataplasia may predict early implantation metastases in the peritoneum. Further distribution of implantation metastases is associated with statistically significant decrease in the area of cancer cells (p=0,034) and increased nuclear/cell ratio (p=0,049). The average life expectancy of women with metastases is inversely proportional to the magnitude of nuclear/cell ratio.
Key words: ovary, endometrial, prognosis, carcinoma, morphology, morphometry, metastasis, cancer