IMMUNOHISTOCHEMICAL ASSESSMENT OF THE EXPRESSION OF MARKER MUSASHI- 1 IN ADENOCARCINOMA AND BENIGN COLON NEOPLASMS
N.А. Nefedova, О.А. Kharlova, P.G. Malkov, N.V. Danilova
The goal of the work was to evaluate and compare the expression of Musashi-1 in adenocarcinoma and benign colon polyps. The study included 32 samples of colon adenocarcinoma and 86 samples of polyps. We carried out immunohistochemical study with anti-Musashi-1 antibody. Cytoplasmic Msi-1 level was significantly higher in adenocarcinomas than in the classical and serrated adenomas (p<0,01). In comparison with other groups, serrated adenomas do not show cytoplasmic Msi-1 expression more frequently. The expression of Msi-1 in benign tumors of the colon was first evaluated. Providing that Musashi-1 is a cancer stem cell marker, serrated lesions have low malignant potential compared with classical adenomas and colon cancer.
Key words: polyps of colon, colorectal cancer, Musashi-1