The aim of the work was to study clinical and morphological aspects of ovarian endometriosis depending on the severity of the disease. Clinical investigation and treatment of 51 patients of reproductive age with ovarian endometriosis was carried out. According to clinical, laboratory and instrumental data, all women were divided into 3 groups: mild, moderate and severe disease. Evaluation of immunohistochemical markers, namely CA-125, glycodelin A and Ki-67, p53, bcl-2, ER, PRA and b-catenin was provided in ovarian tissue; concentration of CA 125 and glycodelin A was recorded in serum and peritoneal fluid. In severe endometriosis CA125 and glycodelin A showed the highest concentrations of serum and peritoneal fluid and high level of expression in endometriotic cyst wall. The expression of Ki-67 and p53 significantly differed in mild and severe endometriosis. The most indicative markers reflecting the severity of endometriosis were CA-125, glycodelin A, Ki-67 and p53.
Key words: ovarian endometriosis, СА 125, glycodelin А, Ki-67, p53, bcl-2, ER, PRA, b-catenin