Serous tubal intraepithelial carcinoma (STIC) is known to be a putative precursor for the most common and aggressive ovarian carcinomas, namely ovarian high-grade serous carcinoma. Precise and early diagnose this disease is therefore one of the priorities for tissue diagnosis in gynecologic oncology. We estimated the application of р16, stathmin1 and laminin-gamma1 as additional markers in the diagnosis of STIC. The study included 70 patients (125 fallopian tubes), all of the specimens were investigated morphologically and immunohistochemically (р53, Ki-67, р16, stathmin1 and laminin-gamma1). Statistics involved exact Fisher’s test and χ2 -test. Expression of p16, stathmin1 and laminin-gamma1 was revealed in 85%, 77,5% and 90% of STIC consequently. In 4 tubes with STIC, only one of these tree markers was positive but we has no cases with all three negative expression. In STIC cases, expression of р16, stathmin1 and laminin-gamma1 was high both in the presence and in the absence of p53 expression in atypical cells. In most cases, positive expression of at least two of the three studied markers was shown. That allows us to recommend their use in cases of absent or questionable p53 expression or boundary indicators of Ki-67 expression.
Key words: serous tubal intraepithelial carcinoma, p16, stathmin1, laminin-gamma1, ovarian high-grade serous carcinoma